學術文章

• Lo RC, Kim H. Histopathological evaluation of liver fibrosis and cirrhosis regression. Clin Mol Hepatol. 2017; 23(4):302-307

• Ng KC, Chok KS, Chan AC, Cheung TT, Wong CL, Fung JY, Yuen J, Poon RTP, Fan ST, Lo CM. Randomized clinical trial of hepatic resection versus radiofrequency ablation for early-stage hepatocellular carcinoma. British Journal of Surgery. 2017; 104(13):1775-1784

• Mak LY, Wong DK, Seto WK, Lai CL, Yuen MF. Hepatitis B core protein as a therapeutic target. Expert Opin Ther Targets. 2017; 21(12):1153-1159

• Tey SK, Tse EYT, Mao X, Ko FCF, Wong AST, Lo RC, Ng IO, Yam JWP. Nuclear Met promotes hepatocellular carcinoma tumorigenesis and metastasis by upregulation of TAK1 and activation of NF-κB pathway. Cancer Lett. 2017; 411:150-161

• Ma KW, Cheung TT, She WH, Chok KS, Chan AC, Dai WC, Lo CM. Risk prediction model for major complication after hepatectomy for malignant tumour - A validated scoring system from a university center. Surg Oncol. 2017; 26(4):446-452

• Cui CP, Wong CC, Kai AK, Ho DW, Lau EY, Tsui YM, Chan LK, Cheung TT, Chok KS, Chan AC, Lo RC, Lee JM, Lee TK, Ng IO. SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop. Gut. 2017; 66(12):2149-2159

• Jiang L, Yan Q, Fang S, Liu M., Li Y, Yuan YF, Li Y, Zhu Y, Qi J, Yang X, Kwong DL, Guan XY. Calcium Binding Protein 39 Promotes Hepatocellular Carcinoma Growth And Metastasis By Activating Erk Signaling Pathway. Hepatology. 2017; 66(5):1529-1545

• Chok KS, Chan AC, Fung JY, Dai WC, Cheung TT, Lo CM. Comparable short- and long-term outcomes in deceased-donor and living-donor liver retransplantation. Hepatol Int. 2017; 11(6):517-522

• Ma KF, Lau EY, Leung DH, Lo J, Ho NP, CHENG YL, Ma SK, Lin C, Copland JA, Ding J, Lo RC, Ng IO, Lee TK. Stearoyl-CoA desaturase regulates sorafenib resistance via modulation of ER stress induced differentiation. Journal of Hepatology. 2017; 67(5):979-990

• Liu AJ, RAO Y, Cheung MP, Hui MN, Wu MH, Chan LK, Ng IO, Niu B, Cheah KS, Sharma R, Hodgson L, Cheung MC. Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration. Nature Communications. 2017; 8(1):1185

• Lam YF, Seto WK, Wong D, Cheung KS, Fung J, Mak LY, Yuen J, Chong CK, Lai CL, Yuen MF. Seven-Year Treatment Outcome of Entecavir in a Real-World Cohort: Effects on Clinical Parameters, HBsAg and HBcrAg Levels. Clin Transl Gastroenterol. 2017; 8(10):e125

• Liu XB, Lo CM, Cheng Q, Ng KT, Shao Y, Li CX, Chung SK, Ng IO, Yu J, Man K. Oval Cells Contribute to Fibrogenesis of Marginal Liver Grafts under Stepwise Regulation of Aldose Reductase and Notch Signaling. Theranostics. 2017; 7(19):4879-4893

• Lee D, Wong CC. The folate cycle is a new metabolic weakness of cancer. Molecular & Cellular Oncology. 2017; 4(6):e1327004

• Fung J, Wong T, Chok KS, Chan AC, Sin SL, Cheung TT, Dai WC, Ng K, Ng KT, Man K, Seto WK, Lai CL, Yuen MF, Lo CM. Oral Nucleos(t)ide Analogs Alone After Liver Transplantation in Chronic Hepatitis B With Preexisting rt204 Mutation. Transplantation. 2017; 101(10):2391-2398

• Tong AC, Ng IO, Lo MC. Immunoglobulin G4-related sclerosing disease involving the mandible. Hong Kong Med J. 2017; 23(5):534-6

• Fung JY, Wong T, Chok KS, Chan AC, Cheung TT, Dai JW, Sin SL, Ma KW, Ng K, Ng KT, Seto WK, Lai CL, Yuen MF, Lo CM. Long-term outcomes of entecavir monotherapy for chronic hepatitis B after liver transplantation: Results up to 8 years. Hepatology. 2017; 66(4):1036-1044

• Wei L, Chiu DK, Tsang FH, Law DC, Cheng CL, Au SL, Lee JM, Wong CC, Ng IO#, Wong CM# (# Corresponding author). Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3. J Hepatol. 2017; 67(4):758-769

• Chiu DK, Tse AP, Xu IM, Cui D, Lai RK, Li LL, Koh HY, Tsang FH, Wei LL, Wong CM, Ng IO, Wong CC. Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma. Nat Commun. 2017; 8(1):517
• Ma KW, Chok KS, Chan AC, Tam SC, Dai WC, Cheung TT, Fung JY, Lo CM. A new formula for estimation of standard liver volume using computed tomography-measured body thickness. Liver Transplantation. 2017; 23(9):1113-1122

• Chan KK, Leung CO, Wong CC, Ho DW, Chok KS, Lai CL, Ng IO, Lo RC. Secretory Stanniocalcin 1 promotes metastasis of hepatocellular carcinoma through activation of JNK signaling pathway. Cancer Lett. 2017; 403:330-338

• Ng KY, Chan JL, Chai S, Tong M, Guan X, Lee NP, Yuan YF, Xie D, Lee TK, Dusetti NJ, Carrier A, Ma SK. TP53INP1 down-regulation activates a p73-dependent DUSP10/ERK signaling pathway to promote metastasis of hepatocellular carcinoma. Cancer Research. 2017; 77(17):4602-4612

• Zhang AY, Lai CL, Huang FY, Seto WK, Fung J, Wong DK, Yuen MF. Deep sequencing analysis of quasispecies in the HBV pre-S region and its association with hepatocellular carcinoma. J Gastroenterol. 2017; 52(9): 1064-1074

• Li J, Mak LY, Wong DK, Fung J, Seto WK, Lai CL, Yuen MF. The role of interleukin-27 in predicting spontaneous HBeAg seroconversion in chronic hepatitis B infection. Liver Int. 2017; 37(9):1287-1294

• Cheung KS, Seto WK, Fung J, Lai CL, Yuen MF. Epidemiology and Natural History of Primary Biliary Cholangitis in the Chinese: A Territory-Based Study in Hong Kong between 2000 and 2015. Clin Transl Gastroenterol. 2017; 8(8):e116

• Lo RC, Leung CO, Chok KS, Ng IO. Variation of stemness markers expression in tumor nodules from synchronous multi-focal hepatocellular carcinoma - an immunohistochemical study. Diagn Pathol. 2017; 12(1):56

• Wu CX, Xu A, Zhang CC, Olson P, Chen L, Lee TK, Cheung TT, Lo CM, Wang XQ. Notch inhibitor (PF-03084014) inhibits hepatocellular carcinoma growth and metastasis via suppression cancer stemness due to reduced activation of Notch1-Stat3. Molecular Cancer Therapeutics. 2017; 16(8):1531-1543

• Chong CK, Cheng CY, Tsoi SY, Huang FY, Liu F, Seto WK, Lai CL, Yuen MF, Wong DK. Role of hepatitis B core protein in HBV transcription and recruitment of histone acetyltransferases to cccDNA minichromosome. Antiviral Res. 2017; 144:1-7

• Cheung KS, Seto WK, Wong DK, Lai CL, Yuen MF. Relationship between HBsAg, HBcrAg and hepatocellular carcinoma in patients with undetectable HBV DNA under nucleos(t)ide therapy. J Viral Hepat. 2017; 24(8):654-661

• Ho DW, Chan LK, Chiu YT, Xu IM, Poon RT, Cheung TT, Tang CN, Tang VW, Lo IL, Lam PW, Yau DT, Li MX, Wong CM#, Ng IO# (# Corresponding author). TSC1/2 mutations define a molecular subset of HCC with aggressive behaviour and treatment implication. Gut. 2017; 66(8):1496-1506

• Yang Y, Zhou Y, Hou J, Bai C, Li Z, Fan J, Ng IO, Zhou W, Sun H, Dong Q, Lee JM, Lo CM, Man K, Yang Y, Li N, Ding G, Yu Y, Cao X. Hepatic IFIT3 predicts interferon-α therapeutic response in patients of hepatocellular carcinoma. Hepatology. 2017; 66(1):152-166

• Wong TL, Che N, Ma S. Reprogramming of Central Carbon Metabolism in Cancer Stem Cells. Biochim Biophys Acata. 2017; 1863(7):1728-1738

• Cheung KS, Seto WK, Wong DK, Mak LY, Lai CL, Yuen MF. Wisteria floribunda agglutinin-positive human Mac-2 binding protein predicts liver cancer development in chronic hepatitis B patients under antiviral treatment. Oncotarget. 2017; 8(29):47507-47517 

• Wong DK, Seto WK, Cheung KS, Chong CK, Huang FY, Fung J, Lai CL, Yuen MF. Hepatitis B virus core-related antigen as a surrogate marker for covalently closed circular DNA. Liver Int. 2017; 37(7):995-1001

• Cheung KS, Seto WK, Fung J, Lai CL, Yuen MF. Prognostic Factors for Transplant-Free Survival and Validation of Prognostic Models in Chinese Patients with Primary Biliary Cholangitis Receiving Ursodeoxycholic Acid. Clin Transl Gastroenterol. 2017; 8(6):e100

• Li WS, Chok KS. Acute hepatitis E virus infection causing acute liver failure requiring living-donor liver transplantation in a non-pregnant immunocompetent woman. Transplant Infectious Disease. 2017; 19(3): e12699

• Tsui YM, Sze KM, Tung EK, Ho DW, Lee TK, Ng IO. Dishevelled-3 phosphorylation is governed by HIPK2/PP1Cα/ITCH axis and the non-phosphorylated form promotes cancer stemness via LGR5 in hepatocellular carcinoma. Oncotarget. 2017; 8(24):39430-39442

• Xia W, Lo CM, Poon RYC, Cheung TT, Chen L, Yang S, Tsao SW, Wang XQ. Smad inhibitor induces CSC differentiation for effective chemosensitization in cyclin D1- and TGF-β/Smad-regulated liver cancer stem cell-like cells. Oncotarget. 2017; 8(24):38811-38824

• Yang S, Wang XQ. XLF-mediated NHEJ activity in hepatocellular carcinoma therapy resistance. BMC Cancer. 2017; 17(1):344

• Lee D, Xu IM, Chiu DK, Lai RK, Tse AP, Lan Li L, Law CT, Tsang FH, Wei LL, Chan CY, Wong CM, Ng IO, Wong CC. Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma. J Clin Invest. 2017; 127(5):1856-1872

• Seto WK, Chan TS, Hwang YY, Wong DK, Fung J, Liu KS, Gill H, Lam YF, Lau EHY, Cheung KS, Lie AKW, Lai CL, Kwong YL, Yuen MF. Hepatitis B reactivation in occult viral carriers undergoing hematopoietic stem cell transplantation: A prospective study. Hepatology. 2017; 65(5):1451-1461

• Chu KK, Chan SC, Sin SL, Chan AC, Chok KS, Cheng IK, Lo CM. Lipid profiles of donors and recipients of liver transplant: like father like son. Hepatology International. 2017; 11(3):300-305

• Kotewall CN, Cheung TT, She WH, Ma KW, Tsang HY, Dai WC, Chan AC, Chok KS, Lo CM. The role of radiofrequency ablation to liver transection surface in patients with close tumor margin of HCC during hepatectomy - a case matched study. Translational Gastroenterology and Hepatology. 2017; 2:33

• Deng JJ, Kong KE, Gao WW, Tang HV, Chaudhary V, Cheng Y, Zhou J, Chan CP, Wong DK, Yuen MF, Jin DY. Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription. Biochim Biophys Acta. 2017; 1860(4):491-501

• Ching RH, Sze KM, Lau EY, Chiu YT, Lee JM, Ng IO, Lee TK. C-terminal truncated hepatitis B virus X protein regulates tumorigenicity, self-renewal and drug resistance via STAT3/Nanog signaling pathway. Oncotarget. 2017; '8(14):23507-23516

• Chok KS, Chan MM, Dai WC, Chan AC, Cheung TT, Wong CL, She WH, Lo CM. Survival outcomes of hepatocellular carcinoma resection with postoperative complications - a propensity-score-matched analysis. Medicine (Baltimore). 2017; 96(12):e6430

• Leong KW, Cheng CW, Wong CM, Ng IO, Kwong YL, Tse E. miR-874-3p is down-regulated in hepatocellular carcinoma and negatively regulates PIN1 expression. Oncotarget. 2017; 8(7):11343-11355

• Seto WK, Lau EH, Wu JT, Hung IF, Leung WK, Cheung KS, Fung J, Lai CL, Yuen MF. Effects of nucleoside analogue prescription for hepatitis B on the incidence of liver cancer in Hong Kong: a territory-wide ecological study. Aliment Pharmacol Ther. 2017; 45(4):501-509

• Seto WK, Yuen MF. Nonalcoholic fatty liver disease in Asia: emerging perspectives. J Gastroenterol. 2017; 52(2):164-174

• Lai CL, Wong D, Ip P, Kopaniszen M, Seto WK, Fung J, Huang FY, Lee B, Cullaro G, Chong CK, Wu R, Cheng C, Yuen J, Ngai V, Yuen MF. Reduction of covalently closed circular DNA with long-term nucleos(t)ide analogue treatment in chronic hepatitis B. Journal of Hepatology. 2017; 66(2):275-281

• Wang XQ, Lo CM, Chen L, Ngan ESW, Xu A, Poon RYC. CDK1-PDK1-PI3K/Akt signaling pathway regulates embryonic and induced pluripotency. Cell Death & Differentiation. 2017; 24(1):38-48

• Chok KS, Fung JY, Chan AC, Dai WC, Sharr WW, Cheung TT, Chan SC, Lo CM. Comparable Short- and Long-term Outcomes in Living Donor and Deceased Donor Liver Transplantations for Patients With Model for End-stage Liver Disease Scores ≥35 in a Hepatitis-B Endemic Area. Ann Surg. 2017; 265(1):173-177
 
• Ching RH, Lau EY, Ling PM, Lee JM, Ma MK, Cheng BY, Lo RC, Ng IO, Lee TK. Phosphorylation of Nucleophosmin at Threonine 234/237 is associated with HCC metastasis. Oncotarget. 2015; 6(41):43483-95

• Fung J, Lo R, Chan SC, Chok KS, Wong T, Sharr W, Cheung TT, Chan AC, Dai WC, Sin SL, Ng IO, Lai CL, Yuen MF, Lo CM. Outcomes including liver histology after liver transplantation for chronic hepatitis B using oral antiviral therapy alone. Liver Transpl. 2015; 21(12):1504-1510

• She WH, Chan AC, Poon RT, Cheung TT, Chok KS, Chan SC, Lo CM. Defining an optimal surgical strategy for synchronous colorectal liver metastases: staged versus simultaneous resection. ANZ J Surg. 2015; 85(11):829-33

• Jiang L, Kwong DL, Li Y, Liu M, Yuan YF, Li Y, Fu L, Guan XY. HBP21, a chaperone of heat shock protein 70, functions as a tumor suppressor in hepatocellular carcinoma. Carcinogenesis. 2015; 36(10):1111-20

• Song Y, Pan G, Chen L, Ma S, Zeng T, Chan TH, Li L, Lian Q, Chow R, Cai X, Li Y, Li Y, Liu M, Li Y, Zhu Y, Wong N, Yuan YF, Pei D, Guan XY. Loss of ATOH8 Increases Stem Cell Features of Hepatocellular Carcinoma Cells. Gastroenterology. 2015; 149(4):1068-1081

• Huang FY, Wong DK, Seto WK, Lai CL, Yuen MF. Estradiol induces apoptosis via activation of miRNA-23a and p53: implication for gender difference in liver cancer development. Oncotarget. 2015; 6(33):34941-52

• Tsang FH, Au SL, Wei L, Fan DN, Lee JM, Wong CC, Ng IO, Wong CM. MicroRNA-142-3p and microRNA-142-5p are downregulated in hepatocellular carcinoma and exhibit synergistic effects on cell motility. Front Med. 2015; 9(3):331-43 

• Ho DW, Kai AK, Ng IO. TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways in hepatocellular carcinoma. Front Med. 2015; 9(3):322-30

• Zhang AY, Lai CL, Huang FY, Seto WK, Fung J, Wong DK, Yuen MF. Evolutionary Changes of Hepatitis B Virus Pre-S Mutations Prior to Development of Hepatocellular Carcinoma. PLoS One. 2015; 10(9):e0139478

• Lo J, Lau EY, Ching RH, Cheng BY, Ma MK, Ng IO, Lee TK. NF-κB mediated CD47 upregulation promotes sorafenib resistance and its blockade synergizes the effect of sorafenib in hepatocellular carcinoma. Hepatology. 2015; 62(2):534-45

• Ho DW, Sze KM, Ng IO. Virus-Clip: a fast and memory-efficient viral integration site detection tool at single-base resolution with annotation capability. Oncotarget. 2015; 6(25):20959-63

• Chan LK, Chiu YT, Sze KM, Ng IO. Tensin4 is up-regulated by EGF-induced ERK1/2 activity and promotes cell proliferation and migration in hepatocellular carcinoma. Oncotarget. 2015; 6(25):20964-76

• Tong M, Fung TM, Luk ST, Ng KY, Lee TK, Lin CH, Yam JW, Chan KW, Ng F, Zheng BJ, Yuan YF, Xie D, Lo CM, Man K, Guan XY, Ma S. ANXA3/JNK Signaling Promotes Self-Renewal and Tumor Growth, and Its Blockade Provides a Therapeutic Target for Hepatocellular Carcinoma. Stem Cell Reports. 2015; 5(1):45-59

• Ng IO, Sze KM, Chu KY. Role of hepatitis B virus X protein in liver cancer. Hong Kong Med J. 2015; 21 Supppl 4:27-30

• Wong CM, Wei L, Au SL, Fan DN, Zhou Y, Tsang FH, Law CT, Lee JM, He X, Shi J, Wong CC, Ng IO. MiR-200b/200c/429 subfamily negatively regulates Rho/ROCK signaling pathway to suppress hepatocellular carcinoma metastasis. Oncotarget. 2015; 6(15):13658-70

• Leung CO, Wong CC, Fan DN, Kai AK, Tung EK, Xu IM, Ng IO, Lo RC. PIM1 regulates glycolysis and promotes tumor progression in hepatocellular carcinoma. Oncotarget. 2015; 6(13):10880-92

• Tsang FH, Au SL, Wei L, Fan DN, Lee JM, Wong CC, Ng IO, Wong CM. Long non-coding RNA HOTTIP is frequently up-regulated in hepatocellular carcinoma and is targeted by tumor suppressive miR-125b. Liver Intl. 2015; 35(5):1597-606

• Seto WK. Hepatitis B virus reactivation during immunosuppressive therapy: Appropriate risk stratification. World J Hepatol. 2015; 7(6):825-30

• Yung MK, Lo KW, Yip CW, Chung GT, Tong CY, Cheung PF, Cheung TT, Poon RT, So S, Fan ST, Cheung ST. Copy number gain of granulin-epithelin precursor (GEP) at chromosome 17q21 associates with overexpression in human liver cancer. BMC Cancer. 2015; 15:264

• Yau TC, Cheng PN, Chan P, Chan L, Yuen J, Pang R, Fan ST, Wheatley DN, Poon RT. Preliminary efficacy, safety, pharmacokinetics, pharmacodynamics and quality of life study of pegylated recombinant human arginase 1 in patients with advanced hepatocellular carcinoma. Invest New Drugs. 2015; 33(2):496-504

• Dai WC, Sharr WW, Chok KS, Cheung TT, Fung JY, Chan AC, Chan SC, Lo CM. Transplantation of a 2-year-old deceased-donor liver to a 61-year-old male recipient. Asian J Surg. 2015; 38(2):113-6

• Chan LH, Luk ST, Ma S. Turning hepatic cancer stem cells inside out--a deeper understanding through multiple perspectives. Mol Cells. 2015; 38(3):202-9

• Fung J, Seto WK, Wong DK, Lai CL, Yuen MF. Hepatitis B surface antigen levels after hepatitis B e-antigen seroclearance: A longitudinal follow-up study. Liver Intl. 2015; 35(3):854-9

• Zhao H, Davies TJ, Ning J, Chang Y, Sachaitr P, Sattler S, Fairchild PJ, Huang FP. A highly optimized protocol for reprogramming cancer cells to pluripotency using nonviral plasmid vectors. Cell Reprogram. 2015; 17(1):7-18

• Ho DW, Ng IO. uGPA: unified Gene Pathway Analyser package for high-throughput genome-wide screening data provides mechanistic overview on human diseases. Clin Chim Acta. 2015; 441:105-8

• Fung J, Lee CK, Chan M, Seto WK, Lai CL, Yuen MF, The Hong Kong Liver Health Census Study Group. High Prevalence of Non-Alcoholic Fatty Liver Disease in the Chinese - Results from the Hong Kong Liver Health Census. Liver Intl. 2015; 35(2):542-9

• Tang HM, Pan K, Kong KY, Hu L, Chan LC, Siu KL, Sun H, Wong CM, Jin DY. Loss of APD1 in yeast confers hydroxyurea sensitivity suppressed by Yap1p transcription factor. Sci Rep. 2015; 5:7987

• Wang J, Liu M, Chen L, Chan TH, Jiang L, Yuan YF, Guan XY. Overexpression of N-terminal kinase like gene promotes tumorigenicity of hepatocellular carcinoma by regulating cell cycle progression and cell motility. Oncotarget. 2015; 6(3):1619-1630
• Wong CC, Au SL, Tse AP, Xu IM, Lai RK, Chiu DK, Wei LL, Fan DN, Tsang FH, Lo RC, Wong CM, Ng IO. Switching of pyruvate kinase isoform L to m2 promotes metabolic reprogramming in hepatocarcinogenesis. PLoS One. 2014; 9(12):e115036

• Cheung  PF, Yip CW, Wong NC, Fong DY, Ng LW, Wan AM, Wong CK, Cheung TT, Ng IO, Poon RT, Fan ST, Cheung ST. Granulin-epithelin precursor renders hepatocellular carcinoma cells resistant to natural killer cytotoxicity. Cancer Immnuol Res. 2014; 2(12):1209-19

• Wong NC, Cheung PF, Yip CW, Chan KF, Ng IO, Fan ST, Cheung ST. Antibody Against Granulin-Epithelin Precursor Sensitizes Hepatocellular Carcinoma to Chemotherapeutic Agents. Mol Cancer Ther. 2014; 13(12):3001-12

• Ma MK, Ng IO, Lee TK. Roles of Stearoyl-CoA Desaturase-1 in Hepatocellular Carcinoma. J Liver Dis Transplant. 2014; 3:2

• Tang HM, Gao WW, Chan CP, Cheng Y, Chaudhary V, Deng JJ, Yuen KS, Wong CM, Ng IO, Kok KH, Zhou J, Jin DY. Requirement of CRTC1 coactivator for hepatitis B virus transcription. Nucleic Acids Res. 2014; 42(20):12455-68

• Wong CC, Tse AP, Huang YP, Zhu YT, Chiu DK, Lai RK, Au SL, Kai AK, Lee JM, Wei LL, Tsang FH, Lo RC, Shi J, Zheng YP, Wong CM, Ng IO. Lysyl oxidase-like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma. Hepatology. 2014; 60(5):1645-58

• Fung J, Wong DK, Seto WK, Kopaniszen M, Lai CL, Yuen MF. Hepatitis B Surface Antigen Seroclearance: Relationship to Hepatitis B e-Antigen Seroclearance and Hepatitis B e-Antigen-Negative Hepatitis. Am J Gastroenterol. 2014; 109(11):1764-70

• Yip CW, Cheung PF, Leung IC, Wong NC, Cheng CK, Fan ST, Cheung ST. Granulin-epithelin precursor interacts with heparan sulfate on liver cancer cells. Carcinogenesis. 2014; 35(11):2485-94

• Seto WK, Wong DK, Fung J, Huang FY, Liu KS, Lai CL, Yuen MF. Linearized hepatitis B surface antigen and hepatitis B core-related antigen in the natural history of chronic hepatitis B. Clin Microbiol Infect. 2014; 20(11):1173-80

• Lai WL, Hung WY, Ching YP. The tumor suppressor, TAX1BP2, is a novel substrate of ATM kinase. Oncogene. 2014; 33(45):5303-9

• Cheung PF, Yip CW, Ng LW, Lo KW, Wong N, Choy KW, Chow C, Chan KF, Cheung TT, Poon RT, Fan ST, Cheung ST. Establishment and characterization of a novel primary hepatocellular carcinoma cell line with metastatic ability in vivo. Cancer Cell Int. 2014; 14(1):103

• Wong DK, Tsoi O, Huang FY, Seto WK, Fung J, Lai CL, Yuen MF. Application of coamplification at lower denaturation temperature-PCR sequencing for early detection of antiviral drug resistance mutations of hepatitis B virus. J Clin Microbiol. 2014; 52(9): 3209-15

• Kido T, Lo RC, Li Y, Lee J, Tabatabai ZL, Ng IO, Lau YF. The potential contributions of a Y-located protooncogene and its X homologue in sexual dimorphisms in hepatocellular carcinoma. Hum Pathol. 2014; 45(9):1847-58

• Wong DK, Kopaniszen M, Omagari K, Tanaka Y, Fong DY, Seto WK, Fung J, Huang FY, Zhang AY, Hung IF, Lai CL, Yuen MF. Effect of hepatitis B virus reverse transcriptase variations on entecavir treatment response. J Infect Dis. 2014; 210(5):701-7

• Chok KS, Cheung TT, Lo RC, Chu FS, Tsang SH, Chan AC, Sharr WW, Fung JY, Dai WC, Chan SC, Fan ST, Lo CM. Pilot study of high-intensity focused ultrasound ablation as a bridging therapy for hepatocellular carcinoma patients wait-listed for liver transplantation. Liver Transpl. 2014; 20(8):912-21

• Tse EY, Ching YP. The role of p21-activated kinases in hepatocellular carcinoma metastasis. J Mol Signal. 2014; 9:7

• Chan AC, Poon RT. Portal Venous Gas and Pneumatosis Intestinalis in Necrotizing Pancreatitis. Clin Gastroenterol Hepatol. 2014; 12(7):e57-8

• Ko FC, Yam JW. Regulation of deleted in liver cancer 1 tumor suppressor by protein-protein interactions and phosphorylation. Int J Cancer. 2014; 135(2):264-9

• Chai S, Tong M, Ng KY, Kwan PS, Chan YP, Fung TM, Lee TK, Wong N, Xie D, Yuan YF, Guan XY, Ma S. Regulatory role of miR-142-3p on the functional hepatic cancer stem cell marker CD133. Oncotarget. 2014; 5(14):5725-35

• Shi KQ, Wu FL, Liu WY, Zhao CC, Chen CX, Xie YY, Wu SJ, Lin XF, Chen YP, Wong DK, Yuen MF, Zheng MH. Non-alcoholic fatty liver disease and risk of in-stent restenosis after bare metal stenting in native coronary arteries. Mol Biol Rep. 2014; 41(7):4713-20

• Zheng MH, Seto WK, Shi KQ, Wong DK, Fung J, Hung IF, Fong DY, Yuen JC, Tong T, Lai CL, Yuen MF. Artificial Neural Network Accurately Predicts Hepatitis B Surface Antigen Seroclearance. PLoS One. 2014; 9(6):e99422

• Huang FY, Wong DK, Seto WK, Zhang AY, Lee CK, Lin CK, Fung J, Lai CL, Yuen MF. Sequence Variations of Full-Length Hepatitis B Virus Genomes in Chinese Patients with HBsAg-Negative Hepatitis B Infection. PLoS One. 2014; 9(6):e99028

• Lee TK, Cheung VC, Lu P, Lau EY, Ma S, Tang KH, Tong M, Lo J, Ng IO. Blockade of CD47 mediated CTSS-PAR2 signaling provides a therapeutic target for hepatocellular carcinoma. Hepatology. 2014; 60(1):179-91

• Yau T, Tang VY, Yao TJ, Fan ST, Lo CM, Poon RT. Development of Hong Kong Liver Cancer Staging System With Treatment Stratification for Patients With Hepatocellular Carcinoma. Gastroenterology. 2014; 146(7):1691-700

• Chan AC, Poon RT, Cheung TT, Chok KS, Chiu DW, Chan SC, Lo CM. Laparoscopic versus open liver resection for elderly patients with malignant liver tumors: a single center experience. J Gastroenterol Hepatol. 2014; 29(6):1279-83

• Wang XQ, Chan KK, Ming X, Lui VCh, Poon RY, Lo CM, Norbury C, Poon RT. G1 checkpoint establishment in vivo during embryonic liver development. BMC Dev Biol. 2014; 14:23

• Ng KT, Lo CM, Guo DY, Qi X, Li CX, Geng W, Liu XB, Ling CC, Ma YY, Yeung WH, Shao, Y, Poon RT, Fan ST, Man K. Identification of transmembrane protein 98 as a novel chemoresistance-conferring gene in hepatocellular carcinoma. Mol Cancer Ther. 2014; 13(5):1285-97

• Sze KM, Chu GK, Mak QH, Lee JM, Ng IO. Proline-rich acidic protein 1 (PRAP1) is a novel interacting partner of MAD1 and has a suppressive role in mitotic checkpoint signalling in hepatocellular carcinoma. J Pathol. 2014; 233(1):51-60

• Lin XF, Shi KQ, You J, Liu WY, Luo YW, Wu FL, Chen YP, Wong DK, Yuen MF, Zheng MH. Increased risk of colorectal malignant neoplasm in patients with nonalcoholic fatty liver disease: a large study. Mol Biol Rep. 2014; 41(5):2989-97

• Seto WK, Lam YF, Fung J, Wong DK, Huang FY, Hung IF, Lai CL, Yuen MF. Changes of HBsAg and HBV DNA levels in Chinese chronic hepatitis B patients after 5 years of entecavir treatment. J Gastroenterol Hepatol. 2014; 29(5):1028-34

• Chan AC, Poon RT, Chok KS, Cheung TT, Chan SC, Lo CM. Feasibility of laparoscopic re-resection for patients with recurrent hepatocellular carcinoma. World J Surg. 2014; 38(5):1141-6

• Chan TH, Lin CH, Qi L, Fei J, Li Y, Yong KJ, Liu M, Song Y, Chow RK, Ng VH, Yuan YF, Tenen DG, Guan XY, Chen L. A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma. Gut. 2014; 63(5):832-43

• Cheung TT, Yuen WK, Poon RT, Chan SC, Fan ST, Lo CM. Improved anterior hepatic transection for isolated hepatocellular carcinoma in the caudate. Hepatobiliary Pancreat Dis Int. 2014; 13(2):219-22

• Chan SC, Chan AC, Sharr WW, Chok KS, Cheung TT, Fan ST, Lo CM. Perpetuating proficiency in donor right hepatectomy for living donor liver transplantation. Asian J Surg. 2014; 37(2):65-72

• Chok KS, Chan SC, Cheung TT, Sharr WW, Chan AC, Fan ST, Lo CM. A Retrospective Study on Risk Factors Associated With Failed Endoscopic Treatment of Biliary Anastomotic Stricture After Right-Lobe Living Donor Liver Transplantation With Duct-to-Duct Anastomosis. Ann Surg. 2014; 259(4):767-72

• Chan SC. Section 2. Small-for-size liver graft and hepatocellular carcinoma recurrence. Transplantation. 2014; 97 Suppl 8:S7-S10

• Lam YF, Wong DK, Seto WK, To KK, Hung IF, Fung J, Lai CL, Yuen MF. HLA-DP and γ-interferon receptor-2 gene variants and their association with viral hepatitis activity in chronic hepatitis B infection. J Gastroenterol Hepatol. 2014; 29(3):533-9

• Fung J, Seto WK, Lai CL, Yuen MF. Extrahepatic effects of nucleoside and nucleotide analogues in chronic hepatitis B treatment. J Gastroenterol Hepatol. 2014; 29(3):428-34

• Jing Y, Jia D, Wong CM, Ng IO, Zhang Z, Liu L, Wang Q, Zhao F, Li J, Yao M, Wu X, He X. SERPINA5 inhibits tumor cell migration by modulating the fibronectin-integrin β1 signaling pathway in hepatocellular carcinoma. Mol Oncol. 2014; 8(2):366-77

• Wong CC, Kai AK, Ng IO. The impact of hypoxia in hepatocellular carcinoma metastasis. Front Med. 2014; 8(1):33-41

• Lam YF, Wong DK, Seto WK, To KK, Hung IF, Fung J, Lai CL, Yuen MF. HLA-DP and interferon gamma receptor-2 gene variants and their association with viral hepatitis activity in chronic hepatitis B infection. J Gastroenterol Hepatol. 2014; 29(3): 533-9

• Chan SC, Chok KS, Sharr WW, Chan AC, Tsang SH, Dai WC, Lo CM. Samaritan donor interchange in living donor liver transplantation. Hepatobiliary Pancreat Dis Int. 2014; 13(1):105-9

• Liu L, Dai Y, Chen J, Zeng T, Li Y, Chen L, Zhu YH, Li Y, Ma S, Xie D, Yuan YF, Guan XY. Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition by way of Akt/GSK-3β/Snail signaling. Hepatology. 2014; 59(2):531-43

• Hou J, Zhou Y, Zheng Y, Fan J, Zhou W, Ng IO, Sun H, Qin L, Qiu S, Lee JM, Lo CM, Man K, Yang Y, Yang Y, Yang Y, Zhang Q, Zhu X, Li N, Wang Z, Ding G, Zhuang SM, Zheng L, Luo X, Xie Y, Liang A, Wang Z, Zhang M, Xia Q, Liang T, Yu Y, Cao X. Hepatic RIG-I Predicts Survival and Interferon-α Therapeutic Response in Hepatocellular Carcinoma. Cancer Cell. 2014; 25(1):49-63
 
• Fung J, Lee CK, Chan M, Seto WK, Wong DK, Lai CL, Yuen MF. Defining Normal Liver Stiffness Range in a Normal Healthy Chinese Population without Liver Disease. PLoS One. 2013; 8(12):e85067

• Chan SC, Sharr WW, Chok KS, Chan AC, Lo CM. Wait and Transplant for Stage 2 Hepatocellular Carcinoma With Deceased-Donor Liver Grafts. Transplantation. 2013; 96(11):995-9

• Lai CL, Yuen MF. Reply: Reduction of cirrhosis and hepatocellular carcinoma with antiviral therapy in chronic hepatitis B. Hepatology. 2013; 58(5):1857

• Cheung TT, Poon RT, Yuen WK, Chok KS, Tsang SH, Yau T, Chan SC, Lo CM. Outcome of laparoscopic versus open hepatectomy for colorectal liver metastases. ANZ J Surg. 2013; 83(11):847-52

• Chan SC, Sharr WW, Cheung TT, Chan AC, Tsang SH, Chok KS, Leung KC, Lo CM. Retrohepatic vena cava deroofing in living donor liver transplantation for caudate hepacellular carcinoma. Hepatobiliary Pancreat Dis Int. 2013; 12(5):552-5

• Seto WK, Liu K, Wong DK, Fung J, Huang FY, Hung IF, Lai CL, Yuen MF. Patterns of hepatitis B surface antigen decline and HBV DNA suppression in Asian treatment-experienced chronic hepatitis B patients after three years of tenofovir treatment. J Hepatol. 2013; 59(4):709-16

• Lo RC. Epithelioid angiomyolipoma of the liver: a clinicopathologic study of 5 cases. Ann Diagn Pathol. 2013; 17(5):412-5

• Chan CP, Kok KH, Tang HM, Wong CM, Jin DY. Internal ribosome entry site-mediated translational regulation of ATF4 splice variant in mammalian unfolded protein response. Biochim Biophys Acta - Mol. Cell Res. 2013; 1833(10):2165-75

• Wang XQ, Ng RK, Ming X, Zhang W, Chen L, Chu AC, Pang R, Lo CM, Tsao SW, Liu X, Poon RT, Fan ST. Epigenetic regulation of pluripotent genes mediates stem cell features in human hepatocellular carcinoma and cancer cell lines. PLoS One. 2013; 8(9):e72435

• Seto WK, Wong DK, Fung J, Huang FY, Lai CL, Yuen MF. Reduction of hepatitis B surface antigen levels and hepatitis B surface antigen seroclearance in chronic hepatitis B patients receiving 10 years of nucleoside analogue therapy. Hepatology. 2013; 58(3):923-31

• Lee TK, Cheung VC, Ng IO. Liver tumor-initiating cells as a therapeutic target for hepatocellular carcinoma. Cancer Lett. 2013; 338(1):101-9

• Li Y, Chen L, Chan TH, Guan XY. Hepatocellular carcinoma: transcriptome diversity regulated by RNA editing. Int J Biochem Cell Biol. 2013; 45(8):1843-8

• Chai S, Ma S. Clinical implications of microRNAs in liver cancer stem cells. Chin J Cancer. 2013; 32(8):419-26

• Seto WK, Wong DK, Lai CL, Yuen MF. Reply to Liao et al. Clin Infect Dis. 2013; 57(4):622

• Wong DK, Seto WK, Fung J, Ip P, Huang FY, Lai CL, Yuen MF. Reduction of hepatitis B surface antigen and covalently closed circular DNA by nucleos(t)ide analogues of different potency. Clin Gastroenterol Hepatol. 2013; 11(8):1004-10

• Cheung TT, Fan ST, Chu FS, Jenkins CR, Chok KS, Tsang SH, Dai WC, Chan AC, Chan SC, Yau TC, Poon RT, Lo CM. Survival analysis of high-intensity focused ultrasound ablation in patients with small hepatocellular carcinoma. HPB (Oxford). 2013; 15(8):567-73 

• Wong LL, Lam IP, Wong TY, Lai WL, Liu HF, Yeung LL, Ching YP. IPA-3 inhibits the growth of liver cancer cells by suppressing PAK1 and NF-κB activation. PLoS One. 2013; 8(7):e68843

• Kok KH, Jin DY. Balance of power in host-virus arms races. Cell Host Microbe. 2013; 14(1):5-6

• Dai Y, Liu L, Zeng T, Zhu YH, Chen L, Li Y, Yuan YF, Ma S, Guan XY. Characterization of the oncogenic function of centromere protein F in hepatocellular carcinoma. Biochem Biophys Res Commun. 2013; 436(4): 711-8

• Seto WK, Tsang OT, Liu K, Chan JM, Wong DK, Fung J, Lai CL, Yuen MF. Role of IL28B and inosine triphosphatase polymorphisms in the treatment of chronic hepatitis C virus genotype 6 infection. J Viral Hepat. 2013; 20(7): 470-7

• Gallagher TK, Chan AC, Poon RT, Cheung TT, Chok KS, Chan SC, Lo CM. Outcomes of central bisectionectomy for hepatocellular carcinoma. HPB (Oxford). 2013; 15(7):529-34

• Cheung TT, Poon RT. Synchronous resections of primary colorectal tumor and liver metastasis by laparoscopic approach. World J Hepatol. 2013; 5(6):298-301

• Au SL, Wong CC, Lee JM, Wong CM, Ng IO. EZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of Deleted in Liver Cancer 1 in Human Cancers. PLoS One. 2013; 8(6):e68226

• Wong DK, Watanabe T, Tanaka Y, Seto WK, Lee CK, Fung J, Lin CK, Huang FY, Lai CL, Yuen MF. Role of HLA-DP polymorphisms on chronicity and disease activity of hepatitis B infection in Southern Chinese. PLoS One. 2013; 8(6):e66920

• Chok KS, Chan SC, Fung JY, Cheung TT, Chan AC, Fan ST, Lo CM. Survival outcomes of right-lobe living donor liver transplantation for patients with high Model for End-stage Liver Disease scores. Hepatobiliary Pancreat Dis Int. 2013; 12(3):256-62

• Fong YK, Chan SC, Cheung TT, Dai WC, Chok KS, Chan AC, Sharr WW, Lo CM. Remnant left liver size and recovery of living right liver donors. Hepatol Int. 2013; 7(2):734-740

• Fung J, Chan SC, Cheung C, Yuen MF, Chok KS, Sharr W, Chan AC, Cheung TT, Seto WK, Fan ST, Lai CL, Lo CM. Oral nucleoside/nucleotide analogs without hepatitis B immune globulin after liver transplantation for hepatitis B. Am J Gastroenterol. 2013; 108(6):942-8

• Au SL, Ng IO, Wong CM. Epigenetic dysregulation in hepatocellular carcinoma: focus on polycomb group proteins. Front Med. 2013; 7(2):231-41

• Seto WK, Wong DK, Kopaniszen M, Proitsi P, Sham PC, Hung IF, Fung J, Lai CL, Yuen MF. HLA-DP and IL28B polymorphisms: Influence of host genome on hepatitis B surface antigen seroclearance in chronic hepatitis B. Clin Infect Dis. 2013; 56(2):1695-703


• Chan AC, Fan ST, Poon RT, Cheung TT, Chok KS, Chan SC, Lo CM. Evaluation of the seventh edition of the American Joint Committee on Cancer tumour-node-metastasis (TNM) staging system for patients undergoing curative resection of hepatocellular carcinoma: implications for the development of a refined staging system. HPB (Oxford). 2013; 15(6):439-48

• Cheung TT, Fan ST, Chan SC, Chok KS, Chu FS, Jenkins CR, Lo RC, Fung JY, Chan AC, Sharr WW, Tsang SH, Dai WC, Poon RT, Lo CM. High-intensity focused ultrasound ablation: An effective bridging therapy for hepatocellular carcinoma patients. World J Gastroenterol. 2013; 19(20):3083-9

• Lo RC, Chan SC, Chan KL, Chiang AK, Lo CM, Ng IO. Post-transplant lymphoproliferative disorders in liver transplant recipients: a clinicopathological study. J Clin Pathol. 2013; 66(5): 392-8

• Cheung TT, Fan ST. Technical note on complete excision of choledochal cysts. Hepatobiliary Pancreat Dis Int. 2013; 12(2):2118-21

• Lo RC, Ng IO. Hepatic Progenitor Cells: Their Role and Functional Significance in the New Classification of Primary Liver Cancers. Liver Cancer. 2013; 2(2):84-92

• Chan AC, Cheung TT, Fan ST, Chok KS, Chan SC, Poon RT, Lo CM. Survival analysis of high-intensity focused ultrasound therapy versus radiofrequency ablation in the treatment of recurrent hepatocellular carcinoma. Ann Surg. 2013; 257(4):686-92

• Chan SC, Fan ST. Selection of patients of hepatocellular carcinoma beyond the Milan criteria for liver transplantation. Hepatobiliary Surg Nutr. 2013; 2(2):84-88

• Chan AC, Chan SC, Chok KS, Cheung TT, Chiu DW, Poon RT, Fan ST, Lo CM. Treatment strategy for recurrent hepatocellular carcinoma: salvage transplantation, repeated resection, or radiofrequency ablation?. Liver Transpl. 2013; 19(4):411-9

• Chan SC, Cheng LC, Ho KL, Chok KS, Sharr WW, Dai WC, Lo CM. Improvising hepatic venous outflow and inferior vena cava reconstruction for combined heart and liver and sequential liver transplantations. Asian J Surg. 2013; 36(2):89-92

• Kim BK, Fung J, Yuen MF, Kim SU. Clinical application of liver stiffness measurement using transient elastography in chronic liver disease from longitudinal perspectives. World J Gastroenterol. 2013; 19(12):1890-900

• Ko FC, Chan LK, Sze KM, Yeung YS, Tse EY, Lu P, Yu MH, Ng IO, Yam JW. PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis. Nat Commun. 2013; 4:1618

• Cheung TT, Poon RT, Yuen WK, Chok KS, Jenkins CR, Chan SC, Fan ST, Lo CM. Long-term survival analysis of pure laparoscopic versus open hepatectomy for hepatocellular carcinoma in patients with cirrhosis: a single-center experience. Ann Surg. 2013; 257(3):506-11

• Seto WK, Wong DK, Fung J, Hung IF, Yuen JC, Tong T, Lai CL, Yuen MF. Serum hepatitis B surface antigen (HBsAg) kinetics in hepatitis B e antigen (HBeAg)-negative chronic hepatitis B. Hepatol Int. 2013; 7(1):119-126

• Seto WK, Wong DK, Fung J, Huang FY, Lai CL, Yuen MF. Reduction of hepatitis B surface antigen levels and HBsAg seroclearance in chronic hepatitis B patients receiving 10 years of nucleoside analogue therapy. Hepatology. 2013; 58(3):923-31

• Seto WK, Tanaka Y, Wong DK, Lai CL, Shinkai N, Yuen JC, Tong T, Fung J, Hung IF, Yuen MF. Evidence of serologic activity in chronic hepatitis B after surface antigen (HBsAg) seroclearance documented by conventional HBsAg assay. Hepatol Int. 2013; 7(1):98-105

• Chok KS, Chan SC, Cheung TT, Chan AC, Sharr WW, Fan ST, Lo CM. Outcomes of side-to-side conversion hepaticojejunostomy for biliary anastomotic stricture after right-liver living donor liver transplantation. Hepatobiliary Pancreat Dis Int. 2013; 12(1):42-6

• Fung J, Lai CL, Yuen MF, Ng IO. Do statins reduce the risk of hepatocellular carcinoma in patients with chronic hepatitis B?. Hepatobiliary Surg Nutr. 2013; 2(1):34-36

• Cheung TT, Ho CL, Lo CM, Chen S, Chan SC, Fung JY, Chan AC, Sharr W, Yau T, Poon RT, Fan ST. 11C-acetate and 18F-FDG PET/CT for clinical staging and selection of patients with hepatocellular carcinoma for liver transplantation on the basis of Milan criteria: surgeon's perspective. J Nucl Med. 54(2):192-200

• Chen L, Li Y, Lin CH, Chan TH, Chow RK, Song Y, Liu M, Yuan YF, Fu L, Kong KL, Qi L, Zhang N, Tong AH, Kwong DL, Man K, Lo CM, Lok S, Tenen DG, Guan XY. Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma. Nat Med. 2013; 19(2):209-16

• Fan DN, Tsang FH, Au SL, Wong CC, Tam AH, Wei L, Lee JM, He X, Ng IO, Wong CM. Histone lysine methyltransferase, suppressor of variegation 3-9 homolog 1, promotes hepatocellular carcinoma progression and is negatively regulated by microRNA-125b. Hepatology. 2013; 57(2):637-47

• Yau T, Cheng PN, Chan P, Chan W, Chen L, Yuen J, Pang R, Fan ST, Poon RT. A phase 1 dose-escalating study of pegylated recombinant human arginase 1 (Peg-rhArg1) in patients with advanced hepatocellular carcinoma. Invest New Drugs. 2013; 31(1): 99-107

• Wong CM, Kai AK, Tsang FH, Ng IO. Regulation of hepatocarcinogenesis by microRNAs. Front Biosci (Elite Ed). 2013; 5:49-60

• Fung J, Yuen MF, Lai CL. The role of steatosis in HBsAg seroclearance for patients with chronic hepatitis B infection: fact or fiction?. Dig Dis Sci. 2013; 58(1): 20-2

• Li Y, Chen L, Chan TH, Liu M, Kong KL, Qiu JL, Yuan YF, Guan XY. SPOCK1 is regulated by CHD1L and blocks apoptosis and promotes HCC cell invasiveness and metastasis in mice. Gastroenterology. 2013; 144(1): 179-191

• Ma S. Biology and clinical implications of CD133(+) liver cancer stem cells. Exp Cell Res. 2013; 319(2): 126-32

• Ma W, Wong CC, Tung EK, Wong CM, Ng IO. RhoE is frequently down-regulated in hepatocellular carcinoma (HCC) and suppresses HCC invasion through antagonizing the Rho/Rho-kinase/myosin phosphatase target pathway. Hepatology. 2013; 57(1): 152-61

• Sze KM, Chu GK, Lee JM, Ng IO. C-terminal truncated HBx is associated with metastasis and enhances invasiveness via C-Jun / MMP10 activation in hepatocellular carcinoma. Hepatology. 2013; 57(1): 131-9

• Lai CL, Yuen MF. Prevention of hepatitis B virus-related hepatocellular carcinoma with antiviral therapy. Hepatology. 2013; 57(1): 399-408


• Chun AC, Kok KH, Jin DY. REV7 is required for anaphase-promoting complex-dependent ubiquitination and degradation of translesion DNA polymerase REV1. Cell Cycle. 2013; 12(2): 365-78
 
• Chew V, Tow C, Huang C, Bard-Chapeau E, Copeland NG, Jenkins NA, Weber A, Lim KH, Toh HC, Heikenwalder M, Ng IO, Nardin A, Abastado JP. Toll-like receptor 3 expressing tumor parenchyma and infiltrating natural killer cells in hepatocellular carcinoma patient. J Natl Cancer Inst. 2012; 104(23); 1796-807

• Yau T, Wong H, Chan P, Yao TJ, Pang R, Cheung TT, Fan ST, Poon RT. Phase II study of bevacizumab and erlotinib in the treatment of advanced hepatocellular carcinoma patients with sorafenib-refractory disease. Invest New Drugs. 2012; 30(6):2384-90

• Tung EK, Ng IO. Significance of serum DKK1 as a diagnostic biomarker in hepatocellular carcinoma. Future Oncol. 2012; 8(12): 1525-8

• Chow AK, Ng L, Sing Li H, Cheng CW, Lam CS, Yau TC, Cheng PN, Fan ST, Poon RT, Pang RW. Anti-tumor efficacy of a recombinant human arginase in human hepatocellular carcinoma. Curr Cancer Drug Targets. 2012; 12(9): 1233-43

• Lai WL, Hung WY, Wong LL, Zhou Y, Leong VY, Lee JM, Ng IO, Jin DY, Ching YP. The centrosomal protein Tax1 binding protein 2 is a novel tumour suppressor in hepatocellular carcinoma regulated by cyclin-dependent kinase 2. Hepatology. 2012; 56(5): 1770-81

• Chiu J, Tang YF, Yao TJ, Wong A, Wong H, Leung R, Chan P, Cheung TT, Chan AC, Pang R, Fan ST, Poon R, Yau T. The use of single-agent sorafenib in the treatment of advanced hepatocellular carcinoma patients with underlying Child-Pugh B liver cirrhosis: A retrospective analysis of efficacy, safety, and survival benefits. Cancer. 2012; 118(21): 5293-301

• Cheung TT, Chu FS, Jenkins CR, Tsang DS, Chok KS, Chan AC, Yau TC, Chan SC, Poon RT, Lo CM, Fan ST. Tolerance of high-intensity focused ultrasound ablation in patients with hepatocellular carcinoma. World J Surg. 2012; 36(10): 2420-7

• Seto WK, Fung J, Yuen MF, Lai CL. Future prevention and treatment of chronic hepatitis B infection. J Clin Gastroenterol. 2012; 46(9):725-34

• Wang XQ, Lo CM, Chen L, Cheung CK, Yang ZF, Chen YX, Ng MN, Yu WC, Ming X, Zhang W, Ho DW, Chan SC, Fan ST. Hematopoietic chimerism in liver transplantation patients and hematopoietic stem/progenitor cells in adult human liver. Hepatology. 2012; 56(4):1557-66

• Tung EK, Ng IO. Considerations in the significance of Dickkopf-1 levels in human hepatocellular carcinoma: authors' reply. Liver Intl. 2012; 32(9):1460-1

• Cheung TT, Chu FS, Jenkins CR, Tsang DS, Chok KS, Chan AC, Yau TC, Chan SC, Poon RT, Lo CM, Fan ST. Tolerance of High-Intensity Focused Ultrasound Ablation in Patients with Hepatocellular Carcinoma. World J Surg. 2012; 36910):2420-7

• Li J, Lau G, Chen L, Yuan YF, Huang J, Luk JM, Xie D, Guan XY. Interleukin 23 promotes hepatocellular carcinoma metastasis via NF-kappa B induced matrix metalloproteinase 9 expression. PLoS One. 2012; 7(9):e46264

• Seto WK, Liu K, Fung J, Wong DK, Yuen JC, Hung IF, Lai CL, Yuen MF. Outcome of lamivudine-resistant chronic hepatitis B after up to 5 years of combination therapy with adefovir. Antivir Ther. 2012; 17(7): 1255-62

• Chan SC, Fan ST, Chok KS, Sharr WW, Dai WC, Fung JY, Chan KY, Balsarkar DJ, Lo CM. Increasing the recipient benefit/donor risk ratio by lowering the graft size requirement for living donor liver transplantation. Liver Transpl. 2012; 18(9):1078-82

• Seto WK, Wong DK, Fung J, Hung IF, Fong DY, Yuen JC, Tong T, Lai CL, Yuen MF. A large case-control study on the predictability of hepatitis B surface antigen levels three years before hepatitis B surface antigen seroclearance. Hepatology. 2012; 56(3):812-9

• Lee CW, Wong LL, Tse EY, Liu HF, Leong VY, Lee JM, Hardie DG, Ng IO, Ching YP. AMPK Promotes p53 Acetylation via Phosphorylation and Inactivation of SIRT1 in Liver Cancer Cells. Cancer Res. 2012; 72(17):4394-404

• Siriwardana RC, Chan SC, Chok KS, Lo CM, Fan ST. Effects of donor steatosis on liver biochemistry and significance of body mass index in predicting steatosis. HPB (Oxford). 2012; 14(9):619-24

• Seto WK, Wong DK, Fung J, Ip PP, Yuen JC, Hung IF, Lai CL, Yuen MF. High Hepatitis B Surface Antigen Levels Predict Insignificant Fibrosis in Hepatitis B e Antigen Positive Chronic Hepatitis B. PLoS One. 2012; 7(8):e43087

• Au SL, Wong CC, Lee JM, Fan DN, Tsang FH, Ng IO, Wong CM. Enhancer of zeste homolog 2 (EZH2) epigenetically silences multiple tumor suppressor miRNAs to promote liver cancer metastasis. Hepatology. 2012; 56(2): 622-31

• Hu L, Liu M, Chen L, Chan TH, Wang J, Huo KK, Zheng BJ, Xie D, Guan XY. SCYL1 binding protein 1 promotes the ubiquitin-dependent degradation of Pirh2 and has tumor-suppressive function in the development of hepatocellular carcinoma. Carcinogenesis. 2012; 33(8):1581-8

• Mak GW, Lai WL, Zhou Y, Li M, Ng IO, Ching YP. CDK5RAP3 Is a Novel Repressor of p14(ARF) in Hepatocellular Carcinoma Cells. PLoS One. 2012; 7(7):e42210

• Lam CY, Yip CW, Poon TC, Cheng CK, Ng EW, Wong NC, Cheung PF, Lai PB, Ng IO, Fan ST, Cheung ST. Identification and characterization of tropomyosin 3 associated with granulin-epithelin precursor in human hepatocellular carcinoma. PLoS One. 2012; 7(7):e40324

• Chok KS, Chan SC, Chan KL, Sharr WW, Tam PK, Fan ST, Lo CM. Bile duct anastomotic stricture after pediatric living donor liver transplantation. J Pediatr Surg. 2012; 47(7):1399-403

• Chen L, Liu C, Ko FC, Xu N, Ng IO, Yam JW, Zhu G. Solution Structure of the Phosphotyrosine Binding (PTB) Domain of Human Tensin2 Protein in Complex with Deleted in Liver Cancer 1 (DLC1) Peptide Reveals a Novel Peptide Binding Mode. J Biol Chem. 2012; 287(31):26104-14

• Siriwardana RC, Lo CM, Chan SC, Fan ST. Role of portal vein embolization in hepatocellular carcinoma management and its effect on recurrence: a case-control study. World J Surg. 2012; 36(7):1640-6

• Chok KS, Fung JY, Chan SC, Cheung TT, Sharr WW, Chan AC, Fan ST, Lo CM. Outcomes of living donor liver transplantation for patients with preoperative type 1 hepatorenal syndrome and acute hepatic decompensation. Liver Transpl. 2012; 18(7):779-85

• Cheung TT, Chan SC, Chok KS, Chan AC, Yu WC, Poon RT, Lo CM, Fan ST. Rapid measurement of indocyanine green retention by pulse spectrophotometry: a validation study in 70 patients with Child-Pugh A cirrhosis before hepatectomy for hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int. 2012; 11(3):267-71

• Wong CM, Ng IO. Reply to: Deregulation of microRNAs expression occurs in stages of multistep hepatocarcinogenesis: Why is it different?. J Hepatol. 2012; 56(6):1426-7

• Chan ST, Fan ST, Chok KS, Cheung TT, Chan AC, Fung JY, Poon RT, Lo CM. Survival advantage of primary liver transplantation for hepatocellular carcinoma within the up-to-7 criteria with microvascular invasion. Hepatol Int. 2012; 6(3):646-656

• Ho DW, Yang ZF, Yi K, Lam CT, Ng MN, Yu WC, Lau J, Wan T, Wang X, Yan Z, Liu H, Zhang Y, Fan ST. Gene expression profiling of liver cancer stem cells by RNA-sequencing. PLoS One. 2012; 7(5):e37159

• Tung EK, Wong BY, Yau TO, Ng IO. Upregulation of the Wnt co-receptor LRP6 promotes hepatocarcinogenesis and enhances cell invasion. PLoS One. 2012; 7(5):e36565

• Wong CM, Wong CC, Lee JM, Fan DN, Au SL, Ng IO. Sequential alterations of miRNA expression in hepatocellular carcinoma development and venous metastasis. Hepatology. 2012; 55(5): 1453-61

• Fan H, Chen L, Zhang F, Quan Y, Su X, Qiu X, Zhao Z, Dong S, Song Y, Chan TH, Guan XY. MTSS1, a novel target of DNA methyltransferase 3B, functions as a tumor suppressor in hepatocellular carcinoma. Oncogene. 2012; 31(18):2298-308

• Chan TH, Chen L, Guan XY. Role of translationally controlled tumor protein in cancer progression. Biochem Res Int. 2012; 2012:369384

• Dai WC, Fan ST, Cheung TT, Chok KS, Chan AC, Tsang SH, Poon RT, Lo CM. The impact of family history of hepatocellular carcinoma on its patients' survival. Hepatobiliary Pancreat Dis Int. 2012; 11(2):160-4

• Seto WK, Lai CL, Yuen MF. Acute-on-chronic liver failure in chronic hepatitis B. J Gastroenterol Hepatol. 2012; 27(4):662-9

• Lei ZQ, Li L, Li GJ, Leung CW, Shi J, Wong CM, Lo KC, Chan KW, Mak CS, Chan SB, Chan NM, Leung CH, La PT, Pong PW. Liver cancer immunoassay with magnetic nanoparticles and MgO-based magnetic tunnel junction sensors. J App Physics. 2012; 111-07E505

• Dai WC, Chan SC, Chok KS, Cheung TT, Sharr WW, Chan AC, Fung JY, Tsang SH, Fan ST, Lo CM. Single-centre experience of liver transplantation for familial amyloidotic polyneuropathy of non-Val30Met variants in Chinese patients. Amyloid. 2012; 19(1):33-6

• Tang KH, Ma S, Lee TK, Chan YP, Kwan PS, Tong CM, Ng IO, Man K, To KF, Lai PB, Lo CM, Guan XY, Chan KW. CD133+ liver tumor-initiating cells promote tumor angiogenesis, growth and self-renewal through neurtensin / IL-8 / CXCL 1 signaling. Hepatology. 2012; 55(3):807-20

• Tse EY, Ko FC, Tung EK, Chan LK, Lee TK, Ngan ES, Man K, Wong AS, Ng IO, Yam JW. Caveolin-1 overexpresion is associated with hepatocellular carinoma tumorigenesis and metastasis. J Pathol. 2012; 226(4):645-53

• Chew V, Chen J, Lee D, Loh E, Lee J, Lim KH, Weber A, Slankamenac K, Poon RT, Yang H, Ooi LL, Toh HC, Heikenwalder M, Ng IO, Nardin A, Abastado JP. Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma. Gut. 2012; 61(3):427-38

• Ng KT, Guo DY, Cheng Q, Geng W, Ling CC, Li CX, Liu XB, Ma YY, Lo CM, Poon RT, Fan ST, Man K. A garlic derivative, S-allylcysteine (SAC), suppresses proliferation and metastasis of hepatocellular carcinoma. PLoS One. 2012; 7(2):e31655

• Seto WK, Lai CL, Ip PP, Fung J, Wong DK, Yuen JC, Hung IF, Yuen MF. A large population histology study showing the lack of association between ALT elevation and significant fibrosis in chronic hepatitis B. PLoS One. 2012; 7(2):e32622

• Li CX, Shao Y, Ng KT, Liu XB, Ling CC, Ma YY, Geng W, Fan ST, Lo CM, Man K. FTY720 suppresses liver tumor metastasis by reducing the population of circulating endothelial progenitor cells. PLoS One. 2012; 7(2):e32380

• Chan TH, Chen L, Liu M, Hu L, Zheng BJ, Poon VK, Huang P, Yuan YF, Huang JD, Yang J, Tsao GS, Guan XY. Translationally controlled tumor protein induces mitotic defects and chromosome missegregation in hepatocellular carcinoma development. Hepatology. 2012; 55(2):491-505

• Chan AC, Poon RT, Cheung TT, Chok KS, Chan SC, Fan ST, Lo CM. Survival analysis of re-resection versus radiofrequency ablation for ntrahepatic recurrence after hepatectomy for hepatocellular carcinoma. World J Surg. 2012; 36(1):151-6
 
• Siriwardana RC, Chan SC, Chok KS, Lo CM, Fan ST. Effects of the liver volume and donor steatosis on errors in the estimated standard liver volume. Liver Transpl. 2011; 17(12): 1437-42

• Cheung PF, Cheng CK, Wong NC, Ho JC, Yip CW, Lui VC, Cheung AN, Fan ST, Cheung ST. Granulin-epithelin precursor is an oncofetal protein defining hepatic cancer stem cells. PLoS One. 2011; 6(12): e28246

• Chan KY, Wong CM, Kwan JS, Lee JM, Cheung KW, Yuen MF, Lai CL, Poon RT, Sham PC, Ng IO. Genome-wide association study of hepatocellular carcinoma in southern Chinese patients with chronic hepatitis B virus infection. PLoS One. 2011; 6(12): e28798

• Chan SC, Lo CM, Chok KS, Sharr WW, Cheung TT, Tsang SH, Chan AC, Fan ST. Modulation of graft vascular inflow guided by flowmetry and manometry in liver transplantation. Hepatobiliary Pancreat Dis Int. 2011; 10(6): 649-56

• Chan SC, Lo CM, Chok KS, Sharr WW, Cheung TT, Tsang SH, Chan AC, Fan ST. Validation of graft and standard liver size predictions in right liver living donor liver transplantation. Hepatol Int. 2011; 5(4): 913-917

• Tung EK, Mak CK, Fatima S, Lo RC, Zhao H, Zhang C, Dai H, Poon RT, Yuen MF, Lai CL, Li JJ, Luk JM, Ng IO. Clinicopathological and prognostic significance of serum and tissue Dickkophf-1 levels in human hepatocellular carcinoma. Liver Intl. 2011; 31(10): 1494-504

• Fan ST, Yang ZF, Ho DW, Ng MN, Yu WC, Wong J. Prediction of posthepatectomy recurrence of hepatocellular carcinoma by circulating cancer stem cells: a prospective study. Ann Surg. 2011; 254(4): 569-76

• Cheung TT, Chan SC, Ho CL, Chok KS, Chan AC, Sharr WW, Ng KK, Poon RT, Lo CM, Fan ST. Can PET with the dual tracers [11C]acetate and [18F]FDG predict microvascular invasion in hepatocellular carcinoma. Liver Transpl. 2011; 17(10): 1218-25

• Fung J, Cheung C, Chan SC, Yuen MF, Chok KS, Sharr W, Dai WC, Chan AC, Cheung TT, Tsang S, Lam B, Lai CL, Lo CM. Entecavir monotherapy is effective in suppressing hepatitis B virus after liver transplantation. Gastroenterology. 2011; 141(4): 1212-9

• Chan LK, Ko FC, Sze KM, Ng IO, Yam JW. Nuclear-targeted Deleted in Liver Cancer 1 (DLC1) is less efficient in exerting its tumor suppressive activity both in vitro and in vivo. PLoS One. 2011; 6(9): e25547

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• Lai RK, Xu IM, Chiu DK, Tse AP, Wei LL, Law CT, Lee D, Wong CM, Wong MP, Ng IO, Wong CC. NDUFA4L2 Fine-tunes Oxidative Stress in Hepatocellular Carcinoma. Clin Cancer Research. 2016; 22(12): 3105-17 • Chiu YT, Ng IO. Gender disparity of hepatocellular carcinoma: role of hepatitis B virus X protein and androgen receptor. Hong Kong Med J. 2016; 22(3 Suppl 4):43-7

• Lau EY, Lo J, Cheng BY, Ma MK, Lee JM, Ng JK, Chai S, Lin CH, Tsang SY, Ma S, Ng IO, Lee TK. Cancer-Associated Fibroblasts Regulate Tumor-Initiating Cell Plasticity in Hepatocellular Carcinoma through c-Met/FRA1/HEY1 Signaling. Cell Rep. 2016; 15(6):1175-89

• Leung CO, Mak WN, Kai AK, Chan KS, Lee TK, Ng IO, Lo RC. Sox9 confers stemness properties in hepatocellular carcinoma through Frizzled-7 mediated Wnt/β-catenin signaling. Oncotarget. 2016; 7(20):29371-86

• Liu M, Chen L, Ma NF, Chow RK, Li Y, Song Y, Chan TH, Fang S, Yang X, Xi S, Jiang L, Li Y, Zeng TT, Li Y, Yuan YF, Guan XY. CHD1L promotes lineage reversion of hepatocellular carcinoma through opening chromatin for key developmental transcription factors. Hepatology. 2016; 63(5):1544-59

• Cheung KS, Seto WK, Lai CL, Yuen MF. Prevention and management of hepatitis B virus reactivation in cancer patients. Hepatol Int. 2016; 10(3):407-14

• Seto WK, Tanaka Y, Wong DK, Shinkai N, Cheung KS, Liu KS, Fung J, Lai CL, Yuen MF. Longitudinal profiles of highly sensitive hepatitis B surface antigen levels: re-evaluation of HBsAg seroclearance. Liver Int. 2016; 36(5):642-50

• Seto WK, Cheung KS, Wong DK, Huang FY, Fung J, Liu KS, Lai CL, Yuen MF. Hepatitis B surface antigen seroclearance during nucleoside analogue therapy: surface antigen kinetics, outcomes, and durability. J Gastroenterol. 2016; 51(5):487-95

• Lo J, Lau EY, So FT, Lu P, Chan VS, Cheung VC, Ching RH, Cheng BY, Ma MK, Ng IO, Lee TK. Anti-CD47 antibody suppresses tumour growth and augments the effect of chemotherapy treatment in hepatocellular carcinoma. Liver Int. 2016; 36(5):737-45

• Ng KY, Chai S, Tong M, Guan XY, Lin CH, Ching YP, Xie D, Cheng AS, Ma S. C-terminal truncated hepatitis B virus X protein promotes hepatocellular carcinogenesis through induction of cancer and stem cell-like properties. Oncotarget. 2016; 7(17): 24005-24017

• Cheng Y, Gao WW, Tang HM, Deng JJ, Wong CM, Chan CP, Jin DY. β-TrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H. Scientific Reports. 2016; 6:23938

• Lo RC, Suriawinata AA, Rubin BP. Liver metastasis of meningeal hemangiopericytoma: a study of 5 cases. Clin Mol Hepatol. 2016; 22(1):188-91

• Xiong L, Teng JL, Botelho MG, Lo RC, Lau SK, Woo PC. Arginine Metabolism in Bacterial Pathogenesis and Cancer Therapy. Int J Mol Sci. 2016; 17(3):363

• Wong DK, Fung J, Lee CK, Seto WK, Leung J, Huang FY, Lin CK, Lai CL, Yuen MF. Intrahepatic hepatitis B virus replication and liver histology in subjects with occult hepatitis B infection. Clin Microbiol Infect. 2016; (3):290.e1-3

• Hung IF, Wong DK, Poon RT, Fong DY, Chui AH, Seto WK, Fung JY, Chan AC, Yuen JC, Tiu R, Choi O, Lai CL, Yuen MF. Risk Factors and Post-Resection Independent Predictive Score for the Recurrence of Hepatitis B-Related Hepatocellular Carcinoma. PLoS One. 2016; 11(2):e0148493

• Xu IM, Lai RK, Lin SH, Tse AP, Chiu DK, Koh HY, Law CT, Wong CM, Cai Z, Wong CC, Ng IO. Transketolase counteracts oxidative stress to drive cancer development. Proc Natl Acad Sci U S A. 2016; 113(6):E725-34

• Wong CM, Wei L, Law CT, Ho DW, Tsang FH, Au SL, Sze KM, Lee JM, Wong CC, Ng IO. Up-regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis. Hepatology. 2016; 63(2):474-87

• CHEN Y, Seto WK, Ho LM, Fung JY, Jim MH, Yip WK, Fan KY, ZHEN Z, Liu J, Yuen MF, Lau CP, Tse HF, Yiu KH. Relation of Tricuspid Regurgitation to Liver Stiffness Measured by Transient Elastography in Patients With Left-Sided Cardiac Valve Disease. Am J Cardiol. 2016; 117(4):640-6

• Yuen MF. Need to improve awareness and management of hepatitis B reactivation in patients receiving immunosuppressive therapy. Hepatol Int. 2016; 10(1):102-5